WebCatalog FieldsAntigen: AXL Receptor Tyrosine Kinase Peptide 2Available to For-Profits: YesAntigen Species: HumanHybridoma Cells Available (Non-Profit): NoIsotype: Rabbit … WebBackground AXL receptor tyrosine kinase (AXL) is a transmembrane protein that is over-expressed in a variety of cancer and immune cells. AXL signaling has been implicated in …
Frontiers The Development of AXL Inhibitors in Lung Cancer: …
WebApr 20, 2006 · The receptor tyrosine kinase Axl (also known as Ufo and Tyro7) belongs to a family of tyrosine receptors that includes Tyro3 (Sky) and Mer (Tyro12). 1,2 A common ligand for Axl family is Gas6 (G rowth a rrest-s pecific protein 6). 2,3 Important cellular functions of Gas6/Axl include cell adhesion, migration, phagocytosis, and inhibition of … WebCatalog FieldsAntigen: AXL Receptor Tyrosine Kinase Peptide 2Available to For-Profits: YesAntigen Species: HumanHybridoma Cells Available (Non-Profit): NoIsotype: Rabbit IgGDepositor: Clinical Proteomics Technologies for CancerHost Species: rabbitAntigen Sequence: Positive Tested Species Reactivity: HumanDepositors Institution: National … tinka\\u0027s new dress
乳腺浸润性导管癌中Axl蛋白的表达及意义_参考网
The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique … See more Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the … See more The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation and survival. Proteolytic … See more Cancer Several drugs classified as "AXL inhibitors" have entered clinical trials; however, many target multiple kinase receptors in addition to AXL. The most advanced AXL selective inhibitor is bemcentinib (BGB324 … See more Axl was first isolated in 1988 and identified as an oncogene in a screen for transforming genes in patients with a chronic myelogenous leukemia See more Studies have shown that AXL knockdown leads to downregulation of transcription factors required for EMT, including Slug, Twist, and Zeb1, and to increased expression of E … See more AXL receptor tyrosine kinase has been shown to interact with TENC1. See more • Neubauer A, Burchert A, Maiwald C, Gruss HJ, Serke S, Huhn D, Wittig B, Liu E (Mar 1997). "Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias". Leukemia & Lymphoma. 25 (1–2): 91–6. See more WebJan 18, 2024 · AXL is a member of the TAM family of receptor tyrosine kinases (RTKs) that also includes TYRO3 and MER. This was the last family of RTKs to be identified and … WebTaken together, our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory … tink dunajska