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WebSep 1, 2002 · The FLT3 gene encodes a 1000– and 993–amino acid protein in the mouse and human, respectively,3,7 and is expressed in immature hematopoietic cells, placenta, gonads, and brain.8,9 Immunoprecipitation studies of FLT3 expressed in COS-7, and in other cell types, demonstrate a major band at about 140 kDa, and a less abundant, more … WebMar 1, 2008 · Mutations of the fms-tyrosine kinase ( FLT3) were first described in 1997 4 and account for the most frequent molecular mutations in AML. 5, 6 The FLT3 gene is a member of the class III receptor tyrosine kinase family, including c-kit, c-fms, and the platelet-derived growth factor receptors. 6,, – 9 In normal bone marrow, FLT3 expression … showertec kelowna
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