NettetAbstract. The term “integrative” as applied to the CNS denotes those functions that are not directly involved in the processing of sensory inputs or in the activity of the motor … Nettet20 timer siden · Similarly, removing Perlecan specifically from neurons, glia or muscle does not cause synaptic retraction, indicating the protein is secreted from multiple cell types and functions non-cell autonomously. Within the peripheral nervous system, Perlecan predominantly localizes to the neural lamella, a specialized ECM surrounding …

Loss of the extracellular matrix protein Perlecan disrupts axonal …

Nettet26. mai 2024 · Understanding cell-type-specific gene regulatory mechanisms from genetic variants to diseases remains challenging. To address this, we developed a computational pipeline, scGRNom (single-cell Gene Regulatory Network prediction from multi-omics), to predict cell-type disease genes and regulatory networks including transcription factors … Nettet9. feb. 2024 · Investigations of brain complex integrative actions should consider beside neural networks, glial, extracellular molecular, and fluid channels networks. The present paper proposes that all these networks are assembled into the brain hyper-network that has as fundamental components, the tetra-partite synapses, formed by neural, glial, … mappi2017 gmail.com

Neuron-Glia Signaling in Synapse Elimination Annual Review of ...

NettetOligodendrocytes are specialised glial cells that myelinate CNS axons. Myelinated axons are bundled together into white matter tracts that interconnect grey matter areas of the brain and are essential for rapid, integrated neuronal communication and cognitive function. Life-long generation of oligodendrocytes is required for myelination of new … NettetDeveloping brain is particularly vulnerable to Pb neurotoxicity because of its immature blood–brain barrier. 16 In fact, chronic early-life exposure to Pb is known to have … NettetDeveloping brain is particularly vulnerable to Pb neurotoxicity because of its immature blood–brain barrier. 16 In fact, chronic early-life exposure to Pb is known to have permanent detrimental effects on development, maintenance and function of the synapses, 16 leading to irreparable neurodevelopmental deficits in sensory-motor and … crozza 18 novembre