Polyneddylation
Web(biochemistry) Multiple neddylation ... Definition from Wiktionary, the free dictionary WebNedd8 is a small ubiquitin-like protein that can be conjugated to substrate-proteins in a process known as neddylation. Although neddylation plays a critical regulatory role in cell …
Polyneddylation
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WebDec 29, 2014 · In contrast, the biological significance of polyneddylation remains to be elucidated. Deneddylation Neddylation is dynamically regulated and counter balanced by the actions of deneddylases, termed deneddylation. WebDec 22, 2014 · However, DEN1 is more active in deneddylating hyper-neddylated cullins, resulting in mono-neddylated substrates 37, which indicates that it might prevent aberrant polyneddylation.
WebAug 1, 2006 · The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). … WebWordSense Dictionary: polyneddylated - spelling, hyphenation, synonyms, translations, meanings & definitions.
WebDec 29, 2014 · It is well-accepted that the length and linkage types of the ubiquitin chain on a given substrate dictate the fate of the ubiquitinated proteins. In contrast, the biological significance of polyneddylation remains to be elucidated. WebJan 7, 2005 · The Essential Functions of NEDD8 are Mediated via Distinct Surface Regions, and Not by Polyneddylation in Schizosaccharomyces pombe, suggesting that mono-ned Dylanation is sufficient for yeast viability under most conditions. Expand
WebImmunocytochemistry assay confirmed that USP7 co‑localizes with PP2A in the cytoplasm and nucleus of HeLa cells. Moreover, western blotting and immunoprecipitation were performed to determine whether polyubiquitination and polyneddylation of PP2A were formed. The results of the present study demonstrated that USP7 was a deubiquitinating ...
WebFeb 5, 2008 · In contrast, multiple lysines of p53 and EGFR seem to be involved in neddylation. 16, 18 Interestingly, in vitro neddylation of Cul-1 resulted in hyperneddylation by immunoblotting analysis, 19 although it is not known whether the hyperneddylation of Cul-1 is due to the formation of multiple mononeddylation or polyneddylation on Cul-1. size of chinese food containersWebHere, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show … sustainability report musim masWebNov 26, 2024 · It is reported that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates and that HYPK functions as an autophagy receptor in the polynedylation-dependent aggrephagy. ABSTRACT Selective degradation of protein aggregates by … sustainability report ocbc nispWebMay 6, 2024 · We also observed several di-glycine remnant peptides of NEDD8 (but not ISG15), indicative of polyneddylation, NEDD8 ubiquitylation or heterotypic ubiquitin-NEDD8 chains 18,31. sustainability report of nikeWebDec 22, 2014 · However, DEN1 is more active in deneddylating hyper-neddylated cullins, resulting in mono-neddylated substrates 37, which indicates that it might prevent aberrant … sustainability report pt bank mandiriWebDec 17, 2024 · Whether polyneddylation with different linkages differentially impacts protein function has thus far remained unknown. Proteome-Wide Identification of NEDD8 Targets. … size of china vs usaWebchains in vivo [26,27], although the function of polyneddylation remains to be determined. NEDD8, like ubiquitin, contains the evolutionary conserved canonical hydrophobic patch, … sustainability report of philippine airlines