WebTFE3 inhibits lipogenesis by suppressing proteolytic processing and activation of sterol regulatory element–binding protein-1c (SREBP-1c) and by interacting with SREBP-1c on … WebImportantly, transcription of the NONO-TFE3 FO is regulated by the strong NONO promoter, resulting in overexpression relative to that of endogenous TFE3 (Yin et al. 2024). Additionally, while endogenous TFE3 is subject to mTORC1-dependent nucleocytoplasmic shuttling, NONO-TFE3 accumulates at high levels in the nucleus ( Kauffman et al. 2014 , …
The Transcription Factor TFEB Links mTORC1 Signaling to
WebThis genetic disease is caused by increased TFE3 expression as a result of translocation of the TFE3 gene on chromosome Xp11.2, 1 and it is associated with cytotoxic chemotherapy in pediatric patients. 11 Table 1 shows currently identified translocations and fused genes that involve TFE3; the number of such gene fusions will increase as in-depth study of this … Web14 Sep 2024 · Disruption of the AFC-specific interfaces of FLCN and FNIP2 with RagC eliminated GAP activity and led to nuclear retention of TFE3, with no effect on mTORC1 … timothy fann obituary
Folliculin promotes substrate-selective mTORC1 activity …
WebAmong the Golgi stress sensors TFE3/TFEB and CREB3, OSW-1 induced dephosphorylation of TFE3/TFEB but not cleavage of CREB3, and induction of the ER stress-inducible genes GADD153 and GADD34 was slight. On the other hand, the induction of LC3-II, an autophagy marker, was more pronounced than the BFA stimulation. WebFigure 1. Metformin inhibits mTOR signaling. (A) Schematic of known AMPK and mTORC1 regulation.(B) Immunoblot analysis of primary serum-starved hepatocytes from wild-type mice treated with increasing doses of metformin (0, 0.5, 1, 2 mM) for 2 or 5 h.(C) Venn diagram of genes regulated in primary hepatocytes by 2 mM metformin (Met) and 0.1 μM … WebTFE3/B arm of mTORC1 signaling is by activating RagC to recruit TFE3 to the mTORC1 complex, i.e., achieving substrate specificity via specific recruitment of substrate to the … timothy fanning facebook