WebHere, we present an integration of scRNA-seq and spatial transcriptomics to study the immune landscape of LN. Specific immune-cell subsets of both normal and LN kidneys were identified and mapped onto the spatial transcriptome slices. APOE+ Mono were shown as the beneficial monocyte/macrophage (Mono/MΦ) in the upstream of LN immune response. Webmacrophage colony-stimulating factor (GMCSF) ARE is known to be a destabilizing element, but its role in translation remains unclear. Here we studied in vivo the role of the GM-CSF ARE on the mRNA and protein expressions of an enhanced green fluorescent protein reporter gene. The GM-CSF ARE had a repressor
CCL21/CCR7 signaling in macrophages promotes joint ... - PubMed
WebThe present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder canc WebHigh helicase subtype was associated with poor clinical outcome, massive M0 macrophage infiltration, and highly active cell proliferation features. ... KIF4A, HJURP, TOP2A, BUB1B, KIF18B, KIF23, and GINS1, were significantly higher in tumor tissues than in paired normal tissues, and a similar phenomenon was observed between C1 and C2. These ... how to know my laptop battery health
Correlation of MKI67 with prognosis, immune infiltration, and T …
Web3.2. top2a的表达与ccrcc临床病理的相关. 通过ualcan数据库分析了top2a mrna与ccrcc病理特征的关联,发现top2a与性别、年龄、病理分期、亚型、临床分期和淋巴结分期中存在差异表达,且差异具有统计学意义(p < 0.05) ();而在性别分组间、年龄分组间相互进行对比,差异无统计学意义(p > 0.05)。 WebA novel mechanism of macrophage-induced anti-androgen resistance* and a promising therapeutic approach** to treat bone metastatic prostate cancer.… Liked by Arian Lundberg Web4. máj 2024 · Purpose High activity of enzyme TOP2a in tumor cells is known to be associated with sensitivity to anthracycline chemotherapy, but 20% of such patients do not show clinical response. Tumor microenvironment, including tumor-associated macrophages (TAM), is an essential factor defining the efficiency of chemotherapy. In the present study, … how to know my laptop generation